Milbemycin oxime was used safely in animals receiving frequently used veterinary products such as vaccines, anthelmintics, antibiotics, steroids, flea collars, shampoos, and dips. In well-controlled clinical field studies 786 dogs completed treatment with milbemycin oxime. Milbemycin oxime has been tested safely in over 75 different breeds of dogs, including collies, pregnant females, breeding males and females, and puppies over two weeks of age. The temporary use of an adulticide product may be necessary to kill these adult fleas. These adult fleas are unable to produce viable offspring. If a SENTINEL Flavor Tabs-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. The concurrent use of an approved adulticide, like CAPSTAR may be employed depending on the severity of the infestation. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. Therefore, noticeable control may not be observed until several weeks after dosing when a pre-existing infestation is present. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. However, pre-existing flea populations may continue to develop and emerge after treatment with SENTINEL Flavor Tabs has begun. SENTINEL Flavor Tabs immediately break the flea life cycle by inhibiting egg development. These reactions are presumably caused by release of protein from dead or dying microfilariae. Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL Flavor Tabs. Prior to administration of SENTINEL Flavor Tabs, dogs should be tested for existing heartworm infections. Without concurrent use of an adulticide, adequate flea control may not be achieved in do g s that have repeated exposure to flea infested animals or environments.ĭo not use in puppies less than four weeks of age and less than two pounds of body weight. Please see the Supplemental Veterinary Package Insert provided with this product for information about concurrent use of the two products, SENTINEL Flavor Tabs may be used con currently with CAPSTAR® (nitenpyram) Tablets to provide a Flea Management System that kills adult fleas and prevents flea eggs from hatching. Concurrent use of adulticide product may be necessary for adequate control of adult fleas. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. SENTINEL Flavor Tabs are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxocara leonina (roundworm) and Trichuris vulpis (whipworm) infections. SENTINEL Flavor Tabs are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. Indications and Usage for Sentinel Flavor Tabs Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron has no effect on the adult flea. Lufenuron’s mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron, the other active ingredient, SENTINEL Flavor Tabs, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm ( Ancylostoma caninum), roundworm ( Toxocara canis and Toxascaris leonine) and whipworm ( Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission.
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